Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.65 |
| ▸ | BTK | Q06187 | 3/20 | 0.65 |
| ▸ | ITK | Q08881 | 3/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | JAK3 | P52333 | 2/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | TEC | P42680 | 1/20 | 0.65 |
| ▸ | TXK | P42681 | 1/20 | 0.65 |
| ▸ | BMX | P51813 | 1/20 | 0.65 |
| ▸ | CD69 | Q07108 | 1/20 | 0.65 |
| ▸ | SYK | P43405 | 6/20 | 0.65 |
| ▸ | AURKA | O14965 | 5/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28704339 | 0.92 | EGFR (0.65) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL29411908 | 0.92 | EGFR (0.65) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL28704792 | 0.91 | EGFR (0.66) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL29411905 | 0.91 | EGFR (0.66) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL28711237 | 0.90 | EGFR (0.72) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL30843981 | 0.90 | EGFR (0.72) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL28960554 | 0.88 | EGFR (0.66) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL28716958 | 0.85 | EGFR (0.61) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL23408964 | 0.85 | SYK (0.68) | EGFRBTKITKJAK2JAK3 | |
| SCHEMBL22909543 | 0.85 | SYK (0.69) | EGFRBTKITKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114181161-B | (2- ((substituted oxy) phenyl) amino) pyrimidin-4-yl) aminobenzoyl derivative and preparation method and application thereof | 南通大学 | 2024-02-27 | — | — | CN | claimed |
| CN-114181161-A | (2- ((substituted oxy) phenyl) amino) pyrimidine-4-yl) aminobenzoyl derivative and preparation method and application thereof | 南通大学 | 2022-03-15 | — | — | CN | claimed |
| CN-114181161-B | (2- ((substituted oxy) phenyl) amino) pyrimidin-4-yl) aminobenzoyl derivative and preparation method and application thereof | 南通大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-114181161-A | (2- ((substituted oxy) phenyl) amino) pyrimidine-4-yl) aminobenzoyl derivative and preparation method and application thereof | 南通大学 | 2022-03-15 | — | — | CN | disclosed |