Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PBK | Q96KB5 | 10/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539263 | 0.75 | HPGD (0.58) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL10412607 | 0.72 | GAA (0.61) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL10412604 | 0.70 | GAA (0.57) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL1580887 | 0.69 | PBK (0.66) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL2340010 | 0.67 | PBK (0.60) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL6783432 | 0.67 | ADORA3 (0.51) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL5541674 | 0.66 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL13495258 | 0.65 | KDM4E (0.51) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL1581142 | 0.64 | ERCC1 (0.52) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL11183576 | 0.64 | RPS6KB2 (0.42) | KDM4EALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110301146-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-12-08 | — | — | US | disclosed |
| WO-2010058512-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010051085-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301146-A1 | GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES | GSK3B, GSK3A, GYS2 | KDM4E 812/4885ALDH1A1 2795/4885HPGD 1587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.