Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001267 | 0.79 | CHKA (0.41) | CHKACYP2D6CYP2C19OPRM1OPRK1 | |
| SCHEMBL1994800 | 0.72 | HRH3 (0.41) | CHKACYP2D6CYP2C19OPRM1OPRK1 | |
| SCHEMBL16121836 | 0.69 | CHKA (1.00) | CHKAALDH1A1KDM4EPOLB | |
| SCHEMBL19367987 | 0.66 | ALDH1A1 (0.59) | CYP2D6CYP2C19HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL16369593 | 0.65 | OPRK1 (0.60) | CYP2D6OPRM1OPRK1HRH3ALDH1A1 | |
| SCHEMBL30341108 | 0.65 | ALDH1A1 (0.73) | CYP2D6CYP2C19HRH3ALDH1A1HTT | |
| SCHEMBL24582827 | 0.64 | HRH3 (0.54) | OPRM1OPRK1HRH3ALDH1A1 | |
| SCHEMBL19634159 | 0.64 | ALDH1A1 (0.67) | ALDH1A1HTTSMN1; SMN2KDM4EPOLB | |
| SCHEMBL25816811 | 0.64 | POLB (0.48) | HRH3ALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL8264510 | 0.64 | ALDH1A1 (0.56) | CYP2D6ALDH1A1SMN1; SMN2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063721-A1 | 1- (BIPHENYL-4-YLMETHYL) IMIDAZOLIDINE-2, 4-DIONE DERIVATIVES AND THEIR USE AS CB2 RECEPTOR AGONISTS | N.V. ORGANON (NL) | 2010-06-10 | — | — | WO | disclosed |