Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL11017422 | 0.99 | MMP2 (0.44) | MMP2GSRGRIK1GRIK2GRM8 | |
| Lysine SCHEMBL28327845 | 0.86 | GSR (0.56) | MMP2GSRGRIK1GRIK2GRM8 | |
| Lysine SCHEMBL28385610 | 0.86 | GSR (0.56) | MMP2GSRGRIK1GRIK2GRM8 | |
| Lysine SCHEMBL27760106 | 0.84 | GSR (0.54) | MMP2GSRGRIK1GRIK2GRM8 | |
| Lysine SCHEMBL27760108 | 0.84 | GSR (0.54) | MMP2GSRGRIK1GRIK2GRM8 | |
| 4-Nitroaniline SCHEMBL27907952 | 0.84 | SLC7A5 (0.51) | GRIK1GRIK2GRM8GRM6GRM4 | |
| 4-Nitroaniline SCHEMBL2934038 | 0.83 | SLC7A5 (0.53) | GRIK1GRIK2GRM8GRM6GRM4 | |
| 4-Nitroaniline SCHEMBL2934041 | 0.83 | SLC7A5 (0.53) | GRIK1GRIK2GRM8GRM6GRM4 | |
| 4-Nitroaniline SCHEMBL11139552 | 0.83 | SLC7A5 (0.53) | GRIK1GRIK2GRM8GRM6GRM4 | |
| 4-Nitroaniline SCHEMBL10773363 | 0.83 | SLC7A5 (0.53) | GRIK1GRIK2GRM8GRM6GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108431045-B | Molecular construct for preventing and/or treating thrombosis | 免疫功坊股份有限公司 | 2022-05-13 | — | — | CN | disclosed |