Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | GPR183 | P32249 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28739134 | 0.91 | HPGD (0.46) | HPGDKMT2ALMNAMAPTHDAC6 | |
| SCHEMBL28739091 | 0.90 | HPGD (0.45) | HPGDKMT2ALMNAMAPTHDAC6 | |
| SCHEMBL22319906 | 0.83 | ABHD6 (0.40) | HPGDKMT2AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL28739104 | 0.80 | PKM (0.50) | HPGDKMT2ALMNAMAPTHDAC6 | |
| SCHEMBL28739242 | 0.79 | ALDH1A1 (0.44) | HPGDKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL29644313 | 0.79 | CA1 (0.53) | HPGDKMT2ALMNAMAPTHDAC6 | |
| SCHEMBL28739107 | 0.79 | CA1 (0.53) | HPGDKMT2ALMNAMAPTHDAC6 | |
| SCHEMBL25381191 | 0.79 | ESR2 (0.46) | MAPTNAMPT | |
| SCHEMBL30678913 | 0.79 | ESR2 (0.46) | MAPTNAMPT | |
| SCHEMBL28738991 | 0.78 | HPGD (0.47) | HPGDKMT2ALMNAMAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114507181-B | Propionic acid compound containing 5-substituted tetrahydroisoquinoline, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-03-26 | — | — | CN | disclosed |
| CN-114507181-A | Propionic acid compound containing 5-substituted tetrahydroisoquinoline, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-05-17 | — | — | CN | disclosed |