Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.38 |
| ▸ | AKT2 | P31751 | 9/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 8/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2874609 | 0.88 | ECE1 (0.43) | SNCA | |
| SCHEMBL2874136 | 0.86 | AKT1 (0.37) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL2873639 | 0.86 | AKT1 (0.45) | AKT1AKT2AKT3EGFRPIM1 | |
| Hydrochloric Acid SCHEMBL2878733 | 0.85 | AKT1 (0.45) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL2876511 | 0.83 | AKT1 (0.35) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL2878514 | 0.78 | AKT1 (0.48) | AKT1AKT2AKT3PIM1MAPKAPK2 | |
| SCHEMBL2876532 | 0.73 | ADORA2A (0.47) | — | |
| SCHEMBL2870786 | 0.72 | SNCA (0.42) | SNCA | |
| SCHEMBL2877014 | 0.71 | JAK2 (0.40) | AKT1AKT3PIM1SYKMAPKAPK2 | |
| SCHEMBL2877013 | 0.71 | PRKCI (0.40) | AKT1AKT3PIM1SYKMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |