Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 17/20 | 0.43 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2874191 | 0.88 | AKT1 (0.38) | SNCA | |
| SCHEMBL2874795 | 0.86 | ECE1 (0.43) | ECE1SNCA | |
| SCHEMBL2873639 | 0.86 | AKT1 (0.45) | ECE1NEK1 | |
| Hydrochloric Acid SCHEMBL2878733 | 0.85 | AKT1 (0.45) | ECE1NEK1 | |
| SCHEMBL2870786 | 0.83 | SNCA (0.42) | ECE1SNCA | |
| SCHEMBL2878514 | 0.78 | AKT1 (0.48) | — | |
| SCHEMBL2874136 | 0.75 | AKT1 (0.37) | SNCA | |
| SCHEMBL2876511 | 0.72 | AKT1 (0.35) | SNCA | |
| SCHEMBL2876674 | 0.71 | ITGB2 (0.43) | ECE1SNCA | |
| SCHEMBL2877014 | 0.71 | JAK2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |