Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 4/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28744834 | 0.86 | POLB (0.45) | POLBCASP6PIN1RAB9ALIPE | |
| SCHEMBL28744862 | 0.83 | POLB (0.43) | POLBCASP6PIN1RAB9ALIPE | |
| SCHEMBL17544730 | 0.81 | PIN1 (0.47) | POLBPIN1ABL1BCRKMT2A | |
| SCHEMBL28744846 | 0.80 | KIF11 (0.43) | POLBCASP6PIN1LIPESMN1; SMN2 | |
| SCHEMBL5258785 | 0.78 | PIN1 (0.45) | POLBCASP6PIN1RAB9ASMN1; SMN2 | |
| SCHEMBL28744873 | 0.77 | MAPK11 (0.34) | ABL1BCRKIF11MEN1KMT2A | |
| SCHEMBL31547647 | 0.77 | PIN1 (0.60) | POLBCASP6PIN1RAB9ASMN1; SMN2 | |
| SCHEMBL17544398 | 0.77 | PIN1 (0.60) | POLBCASP6PIN1RAB9ASMN1; SMN2 | |
| SCHEMBL28744879 | 0.74 | PLAAT3 (0.45) | RAB9ALIPEF2F10SMN1; SMN2 | |
| SCHEMBL4172984 | 0.70 | PIN1 (0.44) | POLBCASP6PIN1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114276331-B | 4-aminopiperidine compound and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-114276331-A | 4-aminopiperidine compound and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2022-04-05 | — | — | CN | disclosed |