Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.43 |
| ▸ | AKT2 | P31751 | 9/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 8/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | PRKX | P51817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2881188 | 0.99 | AKT1 (0.43) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL2879028 | 0.89 | AKT1 (0.36) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL2874136 | 0.86 | AKT1 (0.37) | AKT1AKT2AKT3ROCK1GSK3B | |
| SCHEMBL2873639 | 0.85 | AKT1 (0.45) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL2876490 | 0.85 | AKT1 (0.46) | AKT1AKT2AKT3ROCK1ROCK2 | |
| Hydrochloric Acid SCHEMBL2878733 | 0.84 | AKT1 (0.45) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL2876778 | 0.81 | AKT1 (0.41) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL2874598 | 0.81 | ADORA2A (0.47) | AKT1ROCK1ROCK2GSK3BRPS6KA5 | |
| SCHEMBL2881143 | 0.76 | JAK2 (0.35) | AKT1AKT3ROCK1ROCK2GSK3B | |
| SCHEMBL2881447 | 0.75 | ROCK2 (0.41) | AKT3ROCK1ROCK2GSK3BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |