Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | FLT4 | P35916 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876760 | 0.93 | ROCK2 (0.44) | ROCK2ROCK1AURKAAURKBCHEK1 | |
| SCHEMBL2870470 | 0.92 | ROCK2 (0.43) | ROCK2ROCK1AURKAAURKBCHEK1 | |
| SCHEMBL2876490 | 0.86 | AKT1 (0.46) | ROCK2ROCK1RPS6KB1RPS6KA5MAP4K4 | |
| SCHEMBL2876992 | 0.86 | ROCK2 (0.41) | ROCK2ROCK1AURKAAURKBCHEK1 | |
| SCHEMBL2877177 | 0.83 | ROCK2 (0.41) | ROCK2ROCK1AURKAAURKBCHEK1 | |
| SCHEMBL2878625 | 0.80 | ROCK2 (0.44) | ROCK2ROCK1AURKAAURKBCHEK1 | |
| SCHEMBL2874316 | 0.78 | ROCK2 (0.43) | ROCK2ROCK1AURKAAURKBCHEK1 | |
| SCHEMBL2875905 | 0.78 | ROCK2 (0.42) | ROCK2ROCK1AURKAGPR88DYRK1A | |
| SCHEMBL2876892 | 0.76 | ROCK2 (0.43) | ROCK2ROCK1AURKAAURKBCHEK1 | |
| SCHEMBL2874516 | 0.75 | AKT1 (0.43) | ROCK2ROCK1PRKACARPS6KA5PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |