Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2878998 | 0.88 | PIM1 (0.40) | JAK2LRRK2CDC7PLK4CHEK1 | |
| SCHEMBL2874794 | 0.85 | JAK2 (0.40) | JAK2LRRK2CDC7PLK4CHEK1 | |
| SCHEMBL2874598 | 0.81 | ADORA2A (0.47) | ROCK2MAP4K4PRKCGPRKACARPS6KB1 | |
| SCHEMBL2870454 | 0.78 | CHRM2 (0.38) | CDC7AURKBAKT3 | |
| SCHEMBL2878522 | 0.78 | JAK2 (0.38) | JAK2LRRK2CDC7PLK4CHEK1 | |
| SCHEMBL2876490 | 0.77 | AKT1 (0.46) | MAPK13DYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL2879028 | 0.74 | AKT1 (0.36) | ROCK2PRKACAAKT1GSK3AGSK3B | |
| SCHEMBL2876273 | 0.74 | HPGDS (0.46) | — | |
| SCHEMBL2876743 | 0.74 | NPC1 (0.46) | ROCK2ROCK1 | |
| SCHEMBL2881447 | 0.73 | ROCK2 (0.41) | JAK2CDC7CHEK1ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |