Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197725 | 1.00 | LMNA (0.42) | LMNAS1PR2SMN1; SMN2NPSR1KCNH3 | |
| SCHEMBL6131239 | 1.00 | LMNA (0.42) | LMNAS1PR2SMN1; SMN2NPSR1KCNH3 | |
| SCHEMBL6131249 | 1.00 | LMNA (0.42) | LMNAS1PR2SMN1; SMN2NPSR1KCNH3 | |
| SCHEMBL1974600 | 1.00 | LMNA (0.42) | LMNAS1PR2SMN1; SMN2NPSR1KCNH3 | |
| SCHEMBL8668610 | 1.00 | LMNA (0.42) | LMNAS1PR2SMN1; SMN2NPSR1KCNH3 | |
| SCHEMBL5612995 | 1.00 | LMNA (0.42) | LMNAS1PR2SMN1; SMN2NPSR1KCNH3 | |
| SCHEMBL1414746 | 0.98 | KCNH3 (0.42) | LMNAS1PR2SMN1; SMN2NPSR1KCNH3 | |
| SCHEMBL2328585 | 0.93 | ALDH1A1 (0.40) | LMNASMN1; SMN2NPSR1KCNH3ELANE | |
| SCHEMBL2182651 | 0.85 | IDO1 (0.38) | LMNASIGMAR1ELANEALDH1A1HTT | |
| SCHEMBL2532577 | 0.82 | PRKD3 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072598-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |