Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 8/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.59 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27612525 | 0.80 | ADORA2A (0.63) | ADORA1ADORA2BADORA2APIK3CDABL1 | |
| SCHEMBL5175214 | 0.79 | KDR (0.47) | SYKABCG2EGFRKDR | |
| SCHEMBL27612697 | 0.75 | RHOA (0.58) | SYKABL1 | |
| SCHEMBL28757179 | 0.73 | ABL1 (0.52) | SYKABCG2ABL1SRC | |
| SCHEMBL8973372 | 0.70 | NFKB1 (0.59) | ADORA1ADORA2BSYKCDC7ABCG2 | |
| SCHEMBL27612727 | 0.69 | ADORA2A (0.54) | ADORA1ADORA2BADORA2APIK3CDABL1 | |
| SCHEMBL1039755 | 0.68 | MEN1 (0.50) | ADORA1SYKADORA2AKDR | |
| SCHEMBL953597 | 0.68 | ALDH1A1 (0.56) | SYKCDC7ABCG2SLC2A1EGFR | |
| SCHEMBL23162046 | 0.67 | ADORA2A (0.68) | ADORA1ADORA2BADORA2A | |
| SCHEMBL11581554 | 0.67 | SYK (0.55) | SYKCDC7ABCG2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |