SCHEMBL28754175

SCHEMBL28754175

Cc1ccc([C@@H](O)CCl)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
MAPT P10636 1/20 0.43
LMNA P02545 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
CHRNA7 P36544 1/20 0.39
ACHE P22303 3/20 0.38
AOC3 Q16853 1/20 0.38
TDP1 Q9NUW8 2/20 0.38
TAAR1 Q96RJ0 3/20 0.38
HIF1A Q16665 2/20 0.38
HTR1A P08908 1/20 0.38
THPO P40225 1/20 0.38
BLM P54132 1/20 0.38
NMUR2 Q9GZQ4 1/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP2C9 P11712 1/20 0.38
HTR3A P46098 1/20 0.37
TSHR P16473 1/20 0.37
NFKB1 P19838 1/20 0.37
NR3C2 P08235 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3926773 1.00 ALDH1A1 (0.43) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7
SCHEMBL315436 1.00 ALDH1A1 (0.43) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7
SCHEMBL3920170 0.82 ALDH1A1 (0.41) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7
SCHEMBL3920174 0.82 ALDH1A1 (0.41) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7
SCHEMBL7859393 0.82 ALDH1A1 (0.41) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7
SCHEMBL6579051 0.80 ALDH1A1 (0.40) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7
SCHEMBL6576494 0.80 ALDH1A1 (0.40) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7
SCHEMBL6576487 0.80 ALDH1A1 (0.40) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7
SCHEMBL10799093 0.80 TAAR1 (0.39) ALDH1A1LMNASMN1; SMN2AOC3TDP1
SCHEMBL6493189 0.78 TSHR (0.46) ALDH1A1MAPTLMNASMN1; SMN2CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114560892-A Chiral tridentate nitrogen phosphine ligand synthesized based on ferrocene skeleton and application thereof 广东工业大学 2022-05-31 CN disclosed