Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SELL | P14151 | 1/20 | 0.40 |
| ▸ | SELP | P16109 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049439 | 0.81 | CTNNB1 (0.59) | CTNNB1PARP10HSD17B10MAPTKDM4E | |
| SCHEMBL2714039 | 0.78 | LTA4H (0.48) | HSD17B10MAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL11481998 | 0.75 | CTNNB1 (0.51) | CTNNB1PARP10MAPTALDH1A1SIRT2 | |
| Diphenylether SCHEMBL23068684 | 0.74 | CTNNB1 (0.74) | CTNNB1PARP10HSD17B10MAPTKDM4E | |
| SCHEMBL27991301 | 0.73 | CTNNB1 (0.57) | CTNNB1PARP10KDM4EHPGDALDH1A1 | |
| SCHEMBL27872615 | 0.73 | CTNNB1 (0.57) | CTNNB1PARP10HSD17B10MAPTKDM4E | |
| SCHEMBL9789635 | 0.73 | TTR (0.49) | CTNNB1HSD17B10MAPTKDM4EHPGD | |
| SCHEMBL28081509 | 0.72 | BCAT2 (0.61) | CTNNB1PARP10KDM4EALDH1A1SIRT2 | |
| SCHEMBL28496809 | 0.72 | MAPT (0.50) | HSD17B10MAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL10931576 | 0.71 | LTA4H (0.55) | HSD17B10MAPTKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |