Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | TAF1 | P21675 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29671977 | 0.90 | POLB (0.57) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL28755491 | 0.86 | POLB (0.54) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL28755247 | 0.72 | POLB (1.00) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL28755504 | 0.72 | POLB (0.66) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL28755366 | 0.70 | POLB (0.62) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL3794609 | 0.65 | POLB (0.56) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL3797438 | 0.63 | POLB (0.53) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL14422064 | 0.62 | LMNA (0.53) | POLBKMT2ALMNAALDH1A1BRPF1 | |
| SCHEMBL6646545 | 0.61 | LCK (0.44) | POLBGAAKMT2AHTTTSHR | |
| SCHEMBL6645625 | 0.61 | HRH4 (0.42) | TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573582-B | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2023-06-16 | — | — | CN | disclosed |
| CN-114573582-A | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | disclosed |