Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LGMN | Q99538 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430296 | 0.79 | PDE3B (0.39) | POLBPABPC1KMT2AHTTKDM4E | |
| SCHEMBL13075951 | 0.73 | ALDH1A1 (0.40) | POLBPABPC1KMT2AHTTATAD2 | |
| SCHEMBL611080 | 0.72 | POLB (0.45) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL28755247 | 0.71 | POLB (1.00) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL28755504 | 0.71 | POLB (0.66) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL28755366 | 0.69 | POLB (0.62) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL612453 | 0.68 | ATAD2 (0.44) | GAAKMT2ACYP1A2HTTKDM4E | |
| SCHEMBL29671977 | 0.66 | POLB (0.57) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL11193540 | 0.66 | PDE4A (0.44) | HTTLGMNADORA2AADORA2BPDE4A | |
| SCHEMBL28755319 | 0.65 | POLB (0.56) | POLBPABPC1GAAKMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |