Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | LGMN | Q99538 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794609 | 0.69 | POLB (0.56) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL3797438 | 0.67 | POLB (0.53) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL8530149 | 0.62 | ADORA2A (0.53) | POLBPABPC1GAAKMT2ACYP1A2 | |
| SCHEMBL611080 | 0.60 | POLB (0.45) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL2072539 | 0.59 | ADORA2A (0.48) | POLBPABPC1GAAKMT2ACYP1A2 | |
| SCHEMBL9039030 | 0.58 | PDE3B (0.54) | POLBPABPC1GAAKMT2ACYP2C9 | |
| SCHEMBL4459470 | 0.57 | ALDH1A1 (0.63) | GAAKMT2AALDH1A1PDE3BPDE3A | |
| SCHEMBL27093179 | 0.56 | PDE3B (0.49) | POLBPABPC1CYP2C9CYP1A2KDM4E | |
| SCHEMBL2037400 | 0.56 | LGMN (0.66) | POLBPABPC1GAAKMT2AALDH1A1 | |
| SCHEMBL20608816 | 0.55 | LGMN (0.63) | POLBPABPC1GAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573582-B | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2023-06-16 | — | — | CN | disclosed |
| CN-114573582-A | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | disclosed |