Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of N-(Ethoxycarbonyl)Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 19/20 | 0.61 |
| ▸ | PLAT | P00750 | 4/20 | 0.61 |
| ▸ | PLG | P00747 | 15/20 | 0.58 |
| ▸ | F10 | P00742 | 8/20 | 0.58 |
| ▸ | F2 | P00734 | 7/20 | 0.58 |
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.58 |
| ▸ | HPN | P05981 | 3/20 | 0.58 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.58 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.58 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-(Ethoxycarbonyl)Piperazine SCHEMBL2880394 | 0.98 | PLAU (0.63) | PLAUPLATPLGF10F2 | |
| N-(Ethoxycarbonyl)Piperazine SCHEMBL2875164 | 0.88 | PLAU (0.65) | PLAUPLATPLGF10F2 | |
| N-(Ethoxycarbonyl)Piperazine SCHEMBL1809303 | 0.87 | PLAU (0.67) | PLAUPLATPLGF10F2 | |
| N-(Ethoxycarbonyl)Piperazine SCHEMBL2874625 | 0.86 | PLAU (0.80) | PLAUPLATPLGF10F2 | |
| N-(Ethoxycarbonyl)Piperazine SCHEMBL4606324 | 0.85 | PLAU (0.80) | PLAUPLATPLGF10F2 | |
| N-(Ethoxycarbonyl)Piperazine SCHEMBL3258134 | 0.82 | PLAU (0.51) | PLAUPLATPLGF10F2 | |
| N-(Ethoxycarbonyl)Piperazine SCHEMBL3257068 | 0.80 | PLAU (0.52) | PLAUPLATPLGF10F2 | |
| N-(Ethoxycarbonyl)Piperazine SCHEMBL3660147 | 0.79 | PLAU (0.58) | PLAUPLATPLGF10F2 | |
| N-(Ethoxycarbonyl)Piperazine SCHEMBL3664173 | 0.78 | PLAU (0.54) | PLAUPLATPLGF10F2 | |
| SCHEMBL13727903 | 0.78 | PLAU (0.84) | PLAUPLATPLGF10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713980-B2 | Crystalline modifications of N-α-(2,4,6-triisopropyl-phenylsulfonyl)-3-hydroxyamidino-(L)- phenylalanine 4-ethoxycarbonylpiperazide and/or salts thereof | WILEX AG (DE) | 2010-05-11 | — | — | US | claimed |