SCHEMBL28756264

SCHEMBL28756264

O=C1C=C(c2ccc(Cl)cc2)CCC1

nearest known ligand 0.64

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MT-CO2 P00403 3/20 0.53
SLC6A3 Q01959 3/20 0.41
PTGS2 P35354 2/20 0.41
PTGS1 P23219 1/20 0.41
AKR1C3 P42330 1/20 0.39
AKR1C1 Q04828 1/20 0.39
BRD4 O60885 1/20 0.38
ALDH1A1 P00352 2/20 0.38
SIGMAR1 Q99720 1/20 0.37
SLC6A2 P23975 1/20 0.37
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27720413 0.85 MT-CO2 (0.42) MT-CO2SLC6A3PTGS2ALDH1A1SIGMAR1
SCHEMBL3526596 0.81 MAPT (0.46) SLC6A3PTGS2PTGS1ALDH1A1SLC6A2
SCHEMBL5225774 0.79 HTR2C (0.37) MT-CO2ALDH1A1MAPT
SCHEMBL5793895 0.79 PTGS2 (0.42) PTGS2BRD4ALDH1A1MAPT
SCHEMBL3519376 0.79 MAPK14 (0.41) PTGS2PTGS1ALDH1A1MAPT
SCHEMBL679561 0.78 NPC1 (0.47) ALDH1A1MAPT
SCHEMBL3961649 0.76 ALDH1A1 (0.57) SLC6A3PTGS2PTGS1BRD4ALDH1A1
SCHEMBL11279823 0.75 MAPK14 (0.41) MT-CO2ALDH1A1SIGMAR1MAPT
SCHEMBL31678600 0.75 PTGS2 (0.45) PTGS2PTGS1BRD4
SCHEMBL31678725 0.75 SLC6A2 (0.42) SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114574883-A Method for deoxidizing, hydrogenating and deuterating alpha, beta-unsaturated aldehyde ketone into corresponding olefin and deuterated olefin 南京中医药大学 2022-06-03 CN disclosed