Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31292187 | 0.87 | BRS3 (0.50) | NNMTKMT2AMEN1KDM4EMAPT | |
| SCHEMBL38656126 | 0.78 | NNMT (0.49) | NNMTKMT2AMEN1KDM4EMAPT | |
| SCHEMBL22079377 | 0.76 | NNMT (0.48) | NNMTKMT2AMEN1KDM4EMAPT | |
| SCHEMBL77481 | 0.76 | KDM4E (0.47) | NNMTKMT2AMEN1KDM4EMAPT | |
| SCHEMBL24094522 | 0.75 | SORT1 (0.41) | KMT2AMEN1KDM4ECYP2C19ALDH1A1 | |
| SCHEMBL30318826 | 0.75 | SORT1 (0.41) | KMT2AMEN1KDM4ECYP2C19ALDH1A1 | |
| SCHEMBL4306894 | 0.75 | ACACB (0.43) | NNMTKMT2AMEN1KDM4EMAPT | |
| SCHEMBL26357644 | 0.74 | TSHR (0.40) | NNMTKMT2AMEN1KDM4EMAPT | |
| SCHEMBL22285418 | 0.73 | NNMT (0.47) | NNMTKMT2AMEN1KDM4EMAPT | |
| SCHEMBL38654794 | 0.73 | MAPT (0.50) | KMT2AMEN1MAPTLMNAPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478519-B | Pyrazolopyridine compound or salt thereof, and preparation method and application thereof | 励缔(杭州)医药科技有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-114478519-A | Pyrazolopyridine compound or salt thereof, and preparation method and application thereof | 上海辉启生物医药科技有限公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2022083741-A1 | PYRAZOLOPYRIDINE COMPOUND OR SALT THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海辉启生物医药科技有限公司 | 2022-04-28 | — | — | WO | disclosed |