Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,3-Dimethoxybenzene SCHEMBL27477663 | 0.85 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2TSHRNPSR1L3MBTL1 | |
| Bromide SCHEMBL27655199 | 0.85 | ACHE (0.54) | ALDH1A1SMN1; SMN2ACHECA1CA2 | |
| SCHEMBL20556001 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL27511417 | 0.81 | ACHE (0.54) | ALDH1A1SMN1; SMN2ACHECA1CA2 | |
| Tetrahydrofuran SCHEMBL27323028 | 0.79 | ACHE (0.70) | ALDH1A1SMN1; SMN2TSHRNPSR1L3MBTL1 | |
| Tetrahydrofuran SCHEMBL28746816 | 0.76 | HRH3 (0.47) | ALDH1A1SMN1; SMN2TSHRNPSR1 | |
| Anisole SCHEMBL8850339 | 0.75 | CA4 (0.64) | ALDH1A1SMN1; SMN2TSHRNPSR1L3MBTL1 | |
| Anisole SCHEMBL9859483 | 0.74 | CA4 (0.61) | ALDH1A1SMN1; SMN2TSHRNPSR1L3MBTL1 | |
| Anisole SCHEMBL9436549 | 0.74 | CA4 (0.61) | ALDH1A1SMN1; SMN2TSHRNPSR1L3MBTL1 | |
| Tetrahydrofuran SCHEMBL10496391 | 0.73 | NPC1 (0.52) | ALDH1A1SMN1; SMN2TSHRNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875026-A | Platinum complex and luminescent element | TAKASAGO PERFUMERY CO LTD (JP) | 2006-12-06 | — | — | CN | disclosed |