Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27395573 | 0.87 | TAAR1 (0.58) | TAAR1IDO1AGXTSIGMAR1CHRM2 | |
| Bromide SCHEMBL27455440 | 0.83 | TAAR1 (0.58) | TAAR1IDO1AGXTSIGMAR1CHRM2 | |
| 1,3-Dimethoxybenzene SCHEMBL27477663 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TSHRSMN1; SMN2NPSR1 | |
| Tetrahydrofuran SCHEMBL28758491 | 0.76 | ALDH1A1 (0.43) | ALDH1A1TSHRSMN1; SMN2NPSR1 | |
| Tetrahydrofuran SCHEMBL27323028 | 0.75 | ACHE (0.70) | ALDH1A1TSHRSMN1; SMN2NPSR1 | |
| Tetrahydrofuran SCHEMBL25373074 | 0.74 | FKBP1A (0.40) | ALDH1A1SIGMAR1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL13791587 | 0.72 | SIGMAR1 (0.72) | ALDH1A1SIGMAR1TSHRSMN1; SMN2NPSR1 | |
| Anisole SCHEMBL8850339 | 0.72 | CA4 (0.64) | ALDH1A1SIGMAR1TSHRSMN1; SMN2NPSR1 | |
| Anisole SCHEMBL9436549 | 0.70 | CA4 (0.61) | ALDH1A1SIGMAR1TSHRSMN1; SMN2NPSR1 | |
| Anisole SCHEMBL9859483 | 0.70 | CA4 (0.61) | ALDH1A1SIGMAR1TSHRSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1328550-A | Oxazole compounds as prostaglandin E2 agonists or antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-12-26 | — | — | CN | disclosed |