Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920535 | 0.84 | SLC22A6 (0.45) | SLC22A6MTNR1AMTNR1BSGK1AXL | |
| SCHEMBL9275414 | 0.83 | AURKA (0.43) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL27939090 | 0.82 | SLC22A6 (0.48) | AURKAJAK2MAP4K4FGFR1FLT1 | |
| SCHEMBL27939079 | 0.82 | SLC22A6 (0.44) | DYRK1AJAK2FLT3SLC22A6MTNR1A | |
| SCHEMBL1516568 | 0.80 | DYRK1A (0.48) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL25303525 | 0.80 | DYRK1A (0.50) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL27939107 | 0.79 | ALDH1A1 (0.42) | DYRK1ASLC22A6MTNR1AMTNR1BAAK1 | |
| SCHEMBL412033 | 0.78 | AAK1 (0.43) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL30676600 | 0.75 | AXL (0.63) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL1427263 | 0.75 | AXL (0.63) | DYRK1AAURKAJAK2PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972943-A | New derivatives of 5-aryl-1h-pyrrolo [2, 3b] pyridine-3-carboxamide or 5-aryl-1h-pyrrolo [2, 3b] pyridine-3-carboxylic acid | ASTRAZENECA AB (SE) | 2007-05-30 | — | — | CN | disclosed |