Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 4/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27939090 | 0.84 | SLC22A6 (0.48) | SLC22A6MTNR1AMTNR1BSGK1AXL | |
| SCHEMBL28761614 | 0.84 | DYRK1A (0.44) | SLC22A6MTNR1AMTNR1BSGK1AXL | |
| SCHEMBL27939079 | 0.84 | SLC22A6 (0.44) | SLC22A6MTNR1AMTNR1BSGK1AXL | |
| SCHEMBL27939107 | 0.80 | ALDH1A1 (0.42) | SLC22A6MTNR1AMTNR1BAAK1POLB | |
| SCHEMBL12146867 | 0.80 | CYP2C19 (0.47) | SGK1AXLBRAFAAK1KDM4E | |
| SCHEMBL24565966 | 0.79 | KIT (0.48) | AAK1CYP2C19CYP2C9KITCYP3A4 | |
| SCHEMBL13941746 | 0.74 | AXL (0.50) | SGK1AXLBRAFAAK1CYP2C19 | |
| SCHEMBL30267564 | 0.74 | AXL (0.50) | SGK1AXLBRAFAAK1CYP2C19 | |
| SCHEMBL9938466 | 0.74 | AXL (0.64) | AXLBRAFCYP2C19 | |
| SCHEMBL22049447 | 0.74 | CYP2C9 (0.36) | AAK1CYP2C19CYP2C9KITCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103347874-B | dimeric IAP inhibitors | NOVARTIS AG (CH) | 2014-10-29 | — | — | CN | disclosed |
| CN-103347874-A | Dimeric iap inhibitors | NOVARTIS AG | 2013-10-09 | — | — | CN | disclosed |