Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876426 | 0.85 | HPGDS (0.43) | HPGDSCD274ALDH1A1HTR1AMAOA | |
| SCHEMBL2870481 | 0.81 | CD274 (0.42) | HPGDSCD274ALDH1A1HTR1AMAOA | |
| SCHEMBL2870470 | 0.79 | ROCK2 (0.43) | ALDH1A1KCNH2 | |
| SCHEMBL2874598 | 0.76 | ADORA2A (0.47) | HPGDSALDH1A1 | |
| SCHEMBL2878998 | 0.73 | PIM1 (0.40) | — | |
| SCHEMBL2876743 | 0.71 | NPC1 (0.46) | — | |
| SCHEMBL2876490 | 0.68 | AKT1 (0.46) | — | |
| SCHEMBL2879028 | 0.67 | AKT1 (0.36) | ALDH1A1 | |
| SCHEMBL13852608 | 0.67 | ALDH1A1 (0.62) | CD274ALDH1A1HPGD | |
| SCHEMBL1436987 | 0.66 | ALDH1A1 (0.56) | CD274ALDH1A1HTR1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |