Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6490425 | 0.80 | NPSR1 (0.48) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL2876703 | 0.79 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL24133244 | 0.77 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL15372541 | 0.77 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL9979562 | 0.76 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL15819886 | 0.76 | USP2 (0.53) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL24133236 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL1417326 | 0.75 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL28615512 | 0.74 | POLB (0.47) | ALDH1A1HPGDKDM4EHSD17B10MEN1 | |
| SCHEMBL2876699 | 0.74 | RXRA (0.54) | ALDH1A1HPGDKDM4EHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435946-B1 | LINKED BIARYL COMPOUNDS | AMGEN INC (US) | 2013-11-06 | — | — | EP | disclosed |
| EP-1435946-B1 | LINKED BIARYL COMPOUNDS | AMGEN INC (US) | 2013-11-06 | — | — | EP | disclosed |
| US-7645779-B2 | Linked biaryl compounds | AMGEN INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645779-B2 | Linked biaryl compounds | AMGEN INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645779-B2 | Linked biaryl compounds | AMGEN INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20080161351-A1 | Linked biaryl compounds | TULARIK INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161351-A1 | Linked biaryl compounds | TULARIK INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161351-A1 | Linked biaryl compounds | TULARIK INC. | 2008-07-03 | — | — | US | disclosed |
| EP-1435946-A4 | LINKED BIARYL COMPOUNDS | TULARIK INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6869975-B2 | Linked biaryl compounds | TULARIK INC. (US) | 2005-03-22 | — | — | US | disclosed |
| EP-1435946-A2 | LINKED BIARYL COMPOUNDS | Tularik Inc. (US) | 2004-07-14 | — | — | EP | disclosed |
| US-20030149108-A1 | Linked biaryl compounds | TULARIK INC. | 2003-08-07 | — | — | US | disclosed |
| WO-2003024395-A2 | LINKED BIARYL COMPOUNDS | TULARIK INC. (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149108-A1 | Linked biaryl compounds | SREBF2, SREBF1, ACACB | ALDH1A1 1605/4885HPGD 1302/4885KDM4E 2041/4885 |
| US-20080161351-A1 | Linked biaryl compounds | SREBF2, SREBF1, ACACB | ALDH1A1 1605/4885HPGD 1302/4885KDM4E 2041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.