Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.32 |
| ▸ | KDM6B | O15054 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768366 | 0.90 | TSHR (0.34) | TSHRPOLBTDP1NPC1TP53 | |
| SCHEMBL28768386 | 0.83 | ADRA2A (0.42) | TSHRMAP3K14POLBTDP1KDM4C | |
| SCHEMBL28943661 | 0.81 | TSHR (0.42) | TSHRKDM4CKDM6BNPC1TP53 | |
| SCHEMBL28768183 | 0.81 | MAP3K14 (0.40) | MAP3K14POLBKDM4CKDM6B | |
| SCHEMBL28768211 | 0.81 | KDM4C (0.49) | KDM4CKDM6BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28768120 | 0.79 | SMYD3 (0.36) | KDM4CKDM6B | |
| SCHEMBL28768046 | 0.79 | MGLL (0.39) | KDM4CKDM6B | |
| SCHEMBL28768266 | 0.79 | MAP3K14 (0.41) | MAP3K14TDP1KDM4CKDM6BLMNA | |
| SCHEMBL28768200 | 0.78 | TSHR (0.43) | TSHRPOLBNPC1TP53RAB9A | |
| SCHEMBL23362844 | 0.75 | MAP3K14 (0.37) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114641477-B | Compounds having inhibitory activity on glucosylceramide synthase or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2024-03-12 | — | — | CN | disclosed |
| CN-114641477-A | Novel compound having inhibitory activity against glucose ceramide synthase or pharmaceutically acceptable salt thereof, method for preparing same, and pharmaceutical composition comprising same | 柳韩洋行 | 2022-06-17 | — | — | CN | disclosed |