Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2882414 | 0.90 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2877011 | 0.86 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2882168 | 0.79 | RAB9A (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2881702 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2882294 | 0.76 | FYN (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2209412 | 0.70 | ABL1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2881754 | 0.70 | MAPT (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2214323 | 0.68 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL31351812 | 0.67 | MAPT (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL31351807 | 0.67 | MAPT (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745446-B2 | Pyrazolo[1,5-c]pyrimidines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-29 | — | — | US | disclosed |
| US-20070254046-A1 | Novel Pyrazolopyrimidines | ALTANA PHARMA AG (DE) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254046-A1 | Novel Pyrazolopyrimidines | MCL1, RARS2, CDK4 | KDM4E 3784/4885ALDH1A1 1334/4885HPGD 788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.