Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877115 | 0.87 | TRPV1 (0.39) | TRPV1TRPM8MAPTNPSR1NPC1 | |
| SCHEMBL3811209 | 0.87 | TRPV1 (0.37) | TRPV1TRPM8MAPTNPSR1NPC1 | |
| SCHEMBL2878731 | 0.87 | MAPT (0.44) | TRPV1TRPM8MAPTKDM4EALDH1A1 | |
| SCHEMBL3811154 | 0.86 | TRPV1 (0.37) | TRPV1TRPM8MAPTNPSR1NPC1 | |
| SCHEMBL3809541 | 0.86 | TRPV1 (0.37) | TRPV1TRPM8MAPTNPSR1NPC1 | |
| SCHEMBL3811193 | 0.86 | TRPV1 (0.37) | TRPV1TRPM8MAPTNPSR1NPC1 | |
| SCHEMBL3809145 | 0.84 | TRPV1 (0.38) | TRPV1TRPM8MAPTNPSR1NPC1 | |
| SCHEMBL3807257 | 0.83 | KDM4E (0.39) | TRPV1MAPTNPSR1NPC1RAB9A | |
| SCHEMBL3814603 | 0.81 | TRPV1 (0.35) | TRPV1NPSR1RAB9AKDM4EFASN | |
| SCHEMBL2879577 | 0.80 | GPR88 (0.33) | TRPV1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569929-B9 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2011-09-14 | — | — | EP | claimed |
| EP-1569929-B1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2010-05-05 | — | — | EP | claimed |