Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | WRN | Q14191 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | MLNR | O43193 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811154 | 0.93 | TRPV1 (0.37) | TRPV1TRPM8 | |
| SCHEMBL3809541 | 0.93 | TRPV1 (0.37) | TRPV1TRPM8 | |
| SCHEMBL3811193 | 0.93 | TRPV1 (0.37) | TRPV1TRPM8 | |
| SCHEMBL2874197 | 0.92 | IKBKB (0.35) | GPR88 | |
| SCHEMBL2879446 | 0.88 | GRM5 (0.36) | GPR88POLBS1PR1WRNJAK2 | |
| SCHEMBL2877351 | 0.88 | POLB (0.38) | GPR88POLBJAK2TRPM8 | |
| SCHEMBL2878984 | 0.86 | TRPM8 (0.38) | GPR88TRPV1TRPM8 | |
| SCHEMBL3811209 | 0.84 | TRPV1 (0.37) | GPR88TRPV1TRPM8 | |
| SCHEMBL2875205 | 0.82 | NTMT1 (0.33) | POLB | |
| SCHEMBL3809145 | 0.81 | TRPV1 (0.38) | TRPV1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569929-B9 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2011-09-14 | — | — | EP | claimed |
| EP-1569929-B1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2010-05-05 | — | — | EP | claimed |