Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSH | P09668 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CASP6 | P55212 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3603743 | 0.82 | MEN1 (0.42) | SMN1; SMN2MEN1KMT2ATSHRCTSB | |
| SCHEMBL1559362 | 0.73 | L3MBTL1 (0.40) | MEN1KMT2ATSHRL3MBTL1MAPT | |
| SCHEMBL7604837 | 0.68 | TSHR (0.43) | SMN1; SMN2MEN1KMT2ATSHRCTSB | |
| SCHEMBL14858547 | 0.67 | PKM (0.40) | L3MBTL1MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL17837151 | 0.67 | CYP2C9 (0.42) | SMN1; SMN2MEN1KMT2ATSHRL3MBTL1 | |
| SCHEMBL17396095 | 0.67 | MAPT (0.45) | SMN1; SMN2MEN1KMT2ACTSBCTSH | |
| SCHEMBL2246159 | 0.65 | KMT2A (1.00) | SMN1; SMN2MEN1KMT2ACTSBL3MBTL1 | |
| SCHEMBL28191905 | 0.64 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2ACTSBCTSH | |
| SCHEMBL14599185 | 0.63 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2ATSHRCTSB | |
| SCHEMBL2608494 | 0.63 | GSTP1 (0.61) | SMN1; SMN2MEN1KMT2AL3MBTL1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101553492-A | RAF inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2009-10-07 | — | — | CN | disclosed |