Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2-Phenylbenzo[D]Thiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9098356 | 0.82 | TDP1 (0.54) | ALDH1A1NPC1RAB9AKDM4ETDP1 | |
| SCHEMBL2878011 | 0.81 | MAPT (0.42) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| 2-Phenylbenzo[D]Thiazole SCHEMBL10820979 | 0.81 | RAB9A (0.61) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| 2-Phenylbenzo[D]Thiazole SCHEMBL27864691 | 0.81 | TP53 (0.52) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| SCHEMBL1105447 | 0.80 | APP (0.69) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| SCHEMBL23170966 | 0.80 | MAPT (0.64) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| SCHEMBL30690947 | 0.78 | CYP3A4 (0.57) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| SCHEMBL9004662 | 0.78 | KDM4E (0.63) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| SCHEMBL3679894 | 0.78 | ALDH1A1 (0.78) | ALDH1A1NPC1RAB9AHPGDKDM4E | |
| Biphenyl SCHEMBL1157673 | 0.77 | SMN1; SMN2 (0.58) | ALDH1A1KDM4ETDP1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053218-A1 | FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME | SNU R&DB FOUNDATION (KR) | 2010-05-14 | — | — | WO | disclosed |