SCHEMBL28781306

SCHEMBL28781306

CCOC(=O)CNC1(c2ccc(F)c(F)c2)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.42
HDAC1 Q13547 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.40
KMT2A Q03164 1/20 0.40
ALDH1A1 P00352 3/20 0.39
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
SLC6A3 Q01959 1/20 0.38
PPID Q08752 2/20 0.37
NLRP3 Q96P20 2/20 0.36
KCNN4 O15554 1/20 0.36
OPRM1 P35372 1/20 0.36
POLB P06746 1/20 0.36
PPIB P23284 1/20 0.36
PPIA P62937 1/20 0.36
PPIG Q13427 1/20 0.36
NPC1 O15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30264905 1.00 HDAC3 (0.42) HDAC3HDAC1HDAC2HDAC6HPGD
SCHEMBL23232319 0.87 HDAC3 (0.40) HDAC3HDAC1HDAC2HDAC6HPGD
SCHEMBL23215202 0.80 HDAC6 (0.47) HDAC3HDAC1HDAC2HDAC6SLC6A2
SCHEMBL38655213 0.78 ALDH1A1 (0.41) HPGDKMT2AALDH1A1PPIDOPRM1
SCHEMBL23216359 0.76 NLRP3 (0.41) HPGDTSHRKMT2AALDH1A1SLC6A2
SCHEMBL23216637 0.73 HDAC3 (0.40) HDAC3HDAC1HDAC2HDAC6SLC6A2
SCHEMBL31036999 0.73 HDAC3 (0.46) HDAC3HDAC1HDAC2HDAC6HPGD
SCHEMBL28202864 0.73 OPRM1 (0.56) SLC6A4OPRM1
SCHEMBL28389473 0.73 GRIN2D (0.48) KMT2ASLC6A4PPIDOPRM1POLB
SCHEMBL18742505 0.72 HDAC6 (0.67) HDAC3HDAC1HDAC2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114729044-A Muscarinic acetylcholine M1Receptor antagonists 帕珀莱恩医疗公司 2022-07-08 CN disclosed