Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | UGT1A4 | P22310 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307936 | 0.87 | SCN10A (0.36) | SCN10ACYP19A1UGT1A4PDE4DCNR1 | |
| SCHEMBL27755359 | 0.84 | SCN10A (0.35) | SCN10ACYP19A1UGT1A4PDE4DCNR1 | |
| SCHEMBL27755272 | 0.80 | SCN10A (0.40) | SCN10A | |
| SCHEMBL27775906 | 0.79 | DHODH (0.36) | SCN10ARORCJAK2 | |
| SCHEMBL3944519 | 0.77 | TAAR1 (0.43) | SCN10AHTR1D | |
| SCHEMBL309341 | 0.75 | LOXL2 (0.48) | CYP19A1UGT1A4PDE4DESR1ESR2 | |
| Hydrochloric Acid SCHEMBL3125965 | 0.73 | LOXL2 (0.47) | ESR1ESR2RORC | |
| SCHEMBL6563317 | 0.72 | KIF11 (0.41) | SCN10ACYP19A1UGT1A4PDE4DESR1 | |
| SCHEMBL18560992 | 0.71 | KLF10 (0.43) | SCN10ACNR1CNR2ESR1ESR2 | |
| SCHEMBL17157402 | 0.71 | ESR1 (0.36) | SCN10ACYP19A1UGT1A4PDE4DESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101792436-A | Benzimidazole derivatives used in the treatment of diseases associated with vanilloid receptor 1 | ASTRAZENECA R & D SODERTALJE | 2010-08-04 | — | — | CN | disclosed |
| CN-101522637-A | Benzimidazole derivatives useful for the treatment of vanilloid receptor 1-related disorders | ASTRAZENECA AB (SE) | 2009-09-02 | — | — | CN | disclosed |