Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 16/20 | 0.83 |
| ▸ | KDM1A | O60341 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1814188 | 0.91 | ADAMTS5 (1.00) | ADAMTS5KDM1AKDM4EALOX12L3MBTL1 | |
| SCHEMBL27778698 | 0.89 | ADAMTS5 (0.85) | ADAMTS5KDM1AKDM4EALOX12L3MBTL1 | |
| SCHEMBL1814054 | 0.87 | ADAMTS5 (1.00) | ADAMTS5KDM4EALOX12NPC1HSP90AA1 | |
| SCHEMBL1814561 | 0.86 | ADAMTS5 (1.00) | ADAMTS5NPC1HSP90AA1RAB9A | |
| SCHEMBL27790154 | 0.85 | KDM1A (0.75) | ADAMTS5KDM1AKDM4EALOX12L3MBTL1 | |
| SCHEMBL1817784 | 0.85 | ADAMTS5 (0.80) | ADAMTS5KDM4EALOX12NPC1HSP90AA1 | |
| SCHEMBL27768652 | 0.84 | NPC1 (0.78) | ADAMTS5KDM1AKDM4EALOX12L3MBTL1 | |
| SCHEMBL27757716 | 0.84 | ADAMTS5 (0.85) | ADAMTS5KDM1AKDM4EALOX12L3MBTL1 | |
| SCHEMBL27778697 | 0.83 | ADAMTS5 (0.82) | ADAMTS5KDM4EALOX12L3MBTL1NPC1 | |
| SCHEMBL27768644 | 0.83 | HSP90AA1 (0.70) | ADAMTS5KDM1AKDM4EALOX12L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101505751-A | 8-hydroxyquinoline compounds and methods thereof | WYETH CORP (US) | 2009-08-12 | — | — | CN | claimed |
| CN-101505751-A | 8-hydroxyquinoline compounds and methods thereof | WYETH CORP (US) | 2009-08-12 | — | — | CN | disclosed |