Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 9/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169577 | 0.79 | ACHE (0.56) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL18020161 | 0.79 | TOP1 (1.00) | TOP1NPC1DHODHACHE | |
| SCHEMBL30612203 | 0.76 | L3MBTL1 (0.45) | TOP1NPC1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL26106623 | 0.76 | L3MBTL1 (0.45) | TOP1NPC1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL14034292 | 0.76 | TOP1 (0.42) | TOP1NPC1DHODHKDM4ELMNA | |
| SCHEMBL26649401 | 0.74 | DHODH (0.57) | NPC1DHODHKDM4ELMNASMN1; SMN2 | |
| SCHEMBL19844332 | 0.72 | TOP1 (0.82) | TOP1DHODHKDM4ELMNAMEN1 | |
| SCHEMBL10964842 | 0.71 | METAP1 (0.54) | NPC1DHODHKDM4ELMNASMN1; SMN2 | |
| SCHEMBL27509270 | 0.71 | TLR8 (0.40) | TOP1NPC1KDM4EMEN1HSP90AA1 | |
| SCHEMBL27939580 | 0.70 | CYP19A1 (0.56) | TOP1NPC1DHODHKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101583280-B | Novel hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents | UNIV CHINA MEDICAL | 2013-04-24 | — | — | CN | disclosed |
| CN-101583280-A | Novel hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents | UNIV CHINA MEDICAL (CN) | 2009-11-18 | — | — | CN | disclosed |