Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 10/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19844332 | 0.91 | TOP1 (0.82) | TOP1DHODHACACA | |
| SCHEMBL19986174 | 0.83 | TOP1 (0.71) | TOP1DHODHHSD17B10 | |
| SCHEMBL19986179 | 0.80 | TOP1 (0.67) | TOP1DHODHHSD17B10 | |
| SCHEMBL18292076 | 0.80 | TOP1 (0.64) | TOP1DHODHMAPK1TSHRHSD17B10 | |
| SCHEMBL28784158 | 0.79 | TOP1 (0.65) | TOP1NPC1ACHEDHODH | |
| SCHEMBL23946379 | 0.75 | TOP1 (0.60) | TOP1NPC1MAPK1 | |
| SCHEMBL1042853 | 0.75 | ACACA (0.72) | TOP1ACHEDHODHMAPK1ACACA | |
| SCHEMBL29399315 | 0.75 | ACACA (0.72) | TOP1ACHEDHODHMAPK1ACACA | |
| SCHEMBL28659827 | 0.75 | TOP1 (0.59) | TOP1NPC1MAPK1TSHR | |
| SCHEMBL19986177 | 0.74 | TOP1 (0.59) | TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016128103-A1 | ELECTRONIC DEVICE CONTAINING CYCLIC LACTAMS | MERCK PATENT GMBH (DE) | 2016-08-18 | — | — | WO | disclosed |