Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | DRD4 | P21917 | 4/20 | 0.62 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114590 | 0.85 | KCNH2 (0.68) | MAPTTP53THRBDRD2KCNH2 | |
| SCHEMBL10764516 | 0.84 | HTR1A (0.68) | MAPTTHRBDRD2KCNH2CACNA1G | |
| SCHEMBL3198591 | 0.82 | KCNH2 (0.73) | MAPTTP53DRD2KCNH2DRD4 | |
| Hydrochloric Acid SCHEMBL3212431 | 0.81 | KCNH2 (0.71) | MAPTTP53DRD2KCNH2DRD4 | |
| SCHEMBL27895258 | 0.81 | KCNH2 (0.76) | DRD2KCNH2DRD4CACNA1GHTR1A | |
| SCHEMBL11628265 | 0.81 | DRD2 (0.66) | MAPTTP53THRBDRD2KCNH2 | |
| SCHEMBL6824119 | 0.79 | KCNH2 (0.76) | MAPTDRD2KCNH2GFERSMN1; SMN2 | |
| SCHEMBL15743241 | 0.79 | KCNH2 (0.76) | MAPTTP53DRD2KCNH2DRD4 | |
| SCHEMBL1307825 | 0.79 | KCNH2 (0.76) | MAPTDRD2KCNH2GFERSMN1; SMN2 | |
| SCHEMBL3045487 | 0.79 | KMT2A (0.56) | MAPTDRD2DRD4HTR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101827828-B | 1, 2, 4 -triazole derivatives as serotonergic modulators | PROSARIX LTD | 2013-02-27 | — | — | CN | disclosed |
| CN-101827828-A | 1, 2, 4 -triazole derivatives as serotonergic modulators | PROSARIX LTD | 2010-09-08 | — | — | CN | disclosed |