Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3187979 | 0.83 | DRD2 (0.57) | HTR1ADRD2DRD3DRD4HTR7 | |
| SCHEMBL10764516 | 0.82 | HTR1A (0.68) | KMT2AHTR1ADRD2HTR7MAPT | |
| SCHEMBL520396 | 0.81 | HTR7 (0.56) | KMT2AMEN1ALDH1A1DRD2DRD3 | |
| SCHEMBL31232720 | 0.81 | HTR7 (0.56) | KMT2AMEN1DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL31232759 | 0.80 | HTR7 (0.58) | KMT2AMEN1DRD2DRD3DRD4 | |
| SCHEMBL3055880 | 0.80 | MGLL (0.56) | KMT2AMEN1ALDH1A1HTR1ADRD2 | |
| SCHEMBL2658444 | 0.79 | POLB (0.52) | KMT2AMEN1ALDH1A1DRD2DRD3 | |
| SCHEMBL28784875 | 0.79 | MAPT (0.69) | KMT2AMEN1HTR1ADRD2DRD4 | |
| SCHEMBL3878699 | 0.78 | DRD2 (0.54) | KMT2AMEN1DRD2DRD3DRD4 | |
| SCHEMBL3187986 | 0.78 | DRD2 (0.54) | KMT2AMEN1DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183227-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LTD (GB) | 2014-09-24 | — | — | EP | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-8222254-B2 | 1, 2, 4-triazole derivatives as serotonergic modulators | PROSARIX LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED | 2010-10-14 | — | — | US | disclosed |
| CN-101827828-A | 1, 2, 4 -triazole derivatives as serotonergic modulators | PROSARIX LTD | 2010-09-08 | — | — | CN | disclosed |
| EP-2183227-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | Prosarix Limited (GB) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009019472-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | PROSARIX LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261732-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS | HTR1A, HTR5A, TPH1 | KMT2A 2144/4885MEN1 2932/4885ALDH1A1 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.