Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.42 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581700 | 0.75 | SRD5A1 (0.45) | PARP10PARP11SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL1010625 | 0.75 | MAOA (0.50) | PARP10PARP11SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL5128271 | 0.74 | NOS3 (0.55) | PARP10PARP11CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL31173460 | 0.72 | KDM4E (0.41) | PARP10PARP11SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL11812576 | 0.71 | SRD5A1 (0.53) | PARP10PARP11SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL16400955 | 0.71 | SRD5A1 (0.49) | PARP10PARP11SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL5772636 | 0.71 | PLAU (0.44) | PARP10PARP11SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL31219986 | 0.71 | CYP19A1 (0.41) | PARP10PARP11SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL19794689 | 0.71 | CYP19A1 (0.41) | PARP10PARP11SRD5A1SRD5A2CYP19A1 | |
| SCHEMBL2616887 | 0.71 | MAPK10 (0.47) | PARP10PARP11MAPK10MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101848896-A | Isoquinolinyl and isoindolinyl derivatives as histamine-3 antagonists | WYETH CORP | 2010-09-29 | — | — | CN | disclosed |