Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.55 |
| ▸ | NOS2 | P35228 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24224408 | 0.80 | NOS3 (0.55) | NOS3NOS2KDM4EALDH1A1MAOA | |
| SCHEMBL8523656 | 0.76 | NOS3 (0.50) | NOS3NOS2KDM4EALDH1A1MAOA | |
| SCHEMBL8523658 | 0.76 | NOS3 (0.50) | NOS3NOS2KDM4EALDH1A1MAOA | |
| SCHEMBL28785652 | 0.74 | PARP10 (0.44) | PARP10PARP11CYP19A1CYP11B2CYP11B1 | |
| SCHEMBL28843253 | 0.74 | NOS3 (0.49) | NOS3NOS2KDM4EALDH1A1MAOA | |
| SCHEMBL11488708 | 0.71 | NOS3 (0.59) | NOS3NOS2KDM4EALDH1A1MAOA | |
| SCHEMBL13783121 | 0.71 | NOS3 (0.64) | NOS3NOS2KDM4EALDH1A1MAOA | |
| SCHEMBL11267501 | 0.71 | NOS3 (0.59) | NOS3NOS2KDM4EALDH1A1MAOA | |
| SCHEMBL30310 | 0.71 | NOS3 (0.59) | NOS3NOS2KDM4EALDH1A1MAOA | |
| SCHEMBL4997776 | 0.71 | NOS3 (0.59) | NOS3NOS2KDM4EALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115093369-B | Synthesis method of 3, 4-dihydro-isoquinoline-1-ketone compound | 浙大城市学院 | 2024-05-10 | — | — | CN | claimed |
| CN-117304099-A | Benzene ring compound and application thereof | 上海施江医药科技有限公司 | 2023-12-29 | — | — | CN | claimed |
| CN-117209424-A | Benzene ring compound and application thereof in anti-tumor aspect | 上海施江医药科技有限公司 | 2023-12-12 | — | — | CN | claimed |
| CN-115093369-A | Synthetic method of 3, 4-dihydroisoquinoline-1-ketone compound | 浙大城市学院 | 2022-09-23 | — | — | CN | claimed |
| CN-107778238-B | Novel synthesis method of 3, 4-dihydroisoquinoline-1-ketone | 中山大学 | 2022-07-22 | — | — | CN | claimed |
| CN-107778238-A | A kind of new synthetic method of the ketone of 3,4 dihydro-isoquinoline 1 and isoindoline 1 ketone derivatives | 中山大学 | 2018-03-09 | — | — | CN | claimed |
| CN-107531690-A | The amines of 4,5,6,7 tetrahydrochysene 1H pyrazolos [4,3 c] pyridine 3 as CBP and/or EP300 inhibitor | 基因泰克公司 | 2018-01-02 | — | — | CN | claimed |
| CN-115093369-B | Synthesis method of 3, 4-dihydro-isoquinoline-1-ketone compound | 浙大城市学院 | 2024-05-10 | — | — | CN | disclosed |
| CN-115093369-B | Synthesis method of 3, 4-dihydro-isoquinoline-1-ketone compound | 浙大城市学院 | 2024-05-10 | — | — | CN | disclosed |
| CN-115093369-B | Synthesis method of 3, 4-dihydro-isoquinoline-1-ketone compound | 浙大城市学院 | 2024-05-10 | — | — | CN | disclosed |
| CN-117304099-A | Benzene ring compound and application thereof | 上海施江医药科技有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-117209424-A | Benzene ring compound and application thereof in anti-tumor aspect | 上海施江医药科技有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-117186090-A | Benzene ring compound and application thereof | 上海施江医药科技有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-107531690-A | The amines of 4,5,6,7 tetrahydrochysene 1H pyrazolos [4,3 c] pyridine 3 as CBP and/or EP300 inhibitor | 基因泰克公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-106852142-A | As the spiral shell diamine derivative of aldosterone synthase inhibitors | 豪夫迈·罗氏有限公司 | 2017-06-13 | — | — | CN | disclosed |
| CN-105566221-A | Synthetic method for condensed ring amide compound | GAO YUHUA | 2016-05-11 | — | — | CN | disclosed |
| CN-102448548-A | Heterocyclic antiviral compounds | HOFFMANN LA ROCHE | 2012-05-09 | — | — | CN | disclosed |
| US-20080167314-A1 | Condensed Imidazole Compound And Use Thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-10 | — | — | US | disclosed |
| EP-1832588-A1 | CONDENSED IMIDAZOLE COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-09-12 | — | — | EP | disclosed |
| CN-1135212-A | polar substituted hydrocarbons | NARHEX AUSTRALIA PTY LTD (AU) | 1996-11-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167314-A1 | Condensed Imidazole Compound And Use Thereof | MAPK13, MMP13, MAPK3 | NOS3 11/4885NOS2 44/4885KDM4E 1737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.