SCHEMBL28786162

SCHEMBL28786162

Brc1ccc2[c]c(-c3ccccc3)ccc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.45
CYP19A1 P11511 1/20 0.41
ALDH1A1 P00352 3/20 0.39
MAPK1 P28482 1/20 0.39
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
MAPT P10636 2/20 0.34
KDM4E B2RXH2 1/20 0.34
DCLK1 O15075 1/20 0.33
PRKD3 O94806 1/20 0.33
MAP4K4 O95819 1/20 0.33
CHEK2 O96017 1/20 0.33
CSF1R P07333 1/20 0.33
FER P16591 1/20 0.33
CDK2 P24941 1/20 0.33
MARK3 P27448 1/20 0.33
FLT4 P35916 1/20 0.33
FLT3 P36888 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27822806 0.88 CYP2A6 (0.39) CYP2A6CYP19A1ALDH1A1CYP11B1CYP11B2
SCHEMBL29093556 0.81 ESR1 (0.46) CYP19A1ALDH1A1CYP11B1CYP11B2MEN1
SCHEMBL27802299 0.80 HRH3 (0.39) CYP2A6ALDH1A1CYP11B1CYP11B2MEN1
SCHEMBL27822873 0.80 PNMT (0.38) CYP2A6ALDH1A1CYP11B1CYP11B2MEN1
SCHEMBL27822808 0.79 SMN1; SMN2 (0.41) CYP2A6MEN1KMT2AMAPTDYRK1A
SCHEMBL10594294 0.79 ESR2 (0.52) CYP19A1ALDH1A1CYP11B1CYP11B2MEN1
SCHEMBL27802197 0.79
SCHEMBL7139286 0.78 ALDH1A1 (0.41) CYP2A6ALDH1A1MAPK1MAPTKDM4E
SCHEMBL79020 0.77 ALDH1A1 (0.35) CYP2A6ALDH1A1MEN1KMT2ATSHR
SCHEMBL27822847 0.76 RAB9A (0.33) ALDH1A1MEN1KMT2AMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101977883-A Process for production of 2-hydroxyaryl aldehyde compound NISSAN CHEMICAL IND LTD 2011-02-16 CN disclosed