Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605518 | 0.91 | PARP1 (0.56) | PARP1NUDT1NOTUMPRKCIAXL | |
| SCHEMBL2878520 | 0.85 | NUDT1 (0.48) | NUDT1PRKCIAXLMETIKBKB | |
| SCHEMBL19648515 | 0.78 | PRKCI (0.47) | NUDT1PRKCIAXLMETIKBKB | |
| SCHEMBL12605516 | 0.78 | NUDT1 (0.47) | PARP1NUDT1PRKCIAXLMET | |
| SCHEMBL2876216 | 0.75 | NUDT1 (0.60) | NUDT1PRKCIAXLIKBKBCHUK | |
| SCHEMBL15077817 | 0.74 | PRKCI (0.50) | NUDT1PRKCIAXLIKBKBCHUK | |
| SCHEMBL13069320 | 0.74 | PRKCI (0.50) | NUDT1PRKCIAXLMETIKBKB | |
| SCHEMBL239630 | 0.74 | NUDT1 (0.54) | NUDT1PRKCIAXLIKBKBCHUK | |
| SCHEMBL1748621 | 0.74 | PRKCI (0.53) | NUDT1PRKCIAXLIKBKBCHUK | |
| SCHEMBL28311692 | 0.74 | PRKCI (0.53) | NUDT1PRKCIAXLIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |