Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | PRKX | P51817 | 2/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876879 | 0.82 | ROCK1 (0.48) | MMP13MAPTAURKAROCK1ROCK2 | |
| SCHEMBL2877063 | 0.82 | HPGD (0.48) | MMP13MAPTAURKAROCK1ROCK2 | |
| SCHEMBL2876171 | 0.77 | CDC42BPB (0.41) | ROCK1ROCK2 | |
| SCHEMBL2876524 | 0.74 | ROCK1 (0.36) | ROCK1ROCK2PRKACAPRKXPRKCQ | |
| SCHEMBL2870920 | 0.74 | AKT1 (0.35) | ROCK1ROCK2PRKACAPRKXGSK3A | |
| SCHEMBL2876778 | 0.73 | AKT1 (0.41) | ROCK1ROCK2GSK3B | |
| SCHEMBL2877177 | 0.69 | ROCK2 (0.41) | AURKAROCK1ROCK2PRKACA | |
| SCHEMBL2876743 | 0.69 | NPC1 (0.46) | MMP13ROCK1ROCK2KMT2ANPC1 | |
| SCHEMBL2874598 | 0.67 | ADORA2A (0.47) | MMP13ROCK1ROCK2PRKACAPRKX | |
| SCHEMBL2876532 | 0.67 | ADORA2A (0.47) | MMP13HPGDKMT2ACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |