Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.44 |
| ▸ | CCR1 | P32246 | 13/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639654 | 0.82 | BCL2A1 (0.50) | CCR1SUV39H2 | |
| SCHEMBL1639658 | 0.82 | BCL2A1 (0.50) | CCR1SUV39H2 | |
| SCHEMBL2867159 | 0.82 | BCL2A1 (0.50) | CCR1SUV39H2 | |
| SCHEMBL3315930 | 0.82 | ALDH1A1 (0.58) | — | |
| Hydrochloric Acid SCHEMBL1637572 | 0.81 | BCL2A1 (0.49) | CCR1SUV39H2 | |
| Hydrochloric Acid SCHEMBL1637571 | 0.81 | BCL2A1 (0.49) | CCR1SUV39H2 | |
| SCHEMBL29768447 | 0.81 | NOTUM (0.36) | NOTUM | |
| SCHEMBL13024356 | 0.80 | SUV39H2 (0.60) | CCR1SUV39H2 | |
| SCHEMBL2873572 | 0.80 | SUV39H2 (0.60) | CCR1SUV39H2 | |
| SCHEMBL29768459 | 0.79 | ADRA1D (0.37) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-7842693-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20060106218-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2006-05-18 | — | — | US | disclosed |
| US-20050256130-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2005-11-17 | — | — | US | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
| US-20040162282-A1 | Substituted piperazines | CHEMOCENTRYX, INC. | 2004-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106218-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | NOTUM 4580/4885CCR1 1/4885SUV39H2 3078/4885 |
| US-20050256130-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | NOTUM 4580/4885CCR1 1/4885SUV39H2 3078/4885 |
| US-20040162282-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | NOTUM 4652/4885CCR1 1/4885SUV39H2 2585/4885 |
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CCR1, CCR3, CCRL2 | NOTUM 4580/4885CCR1 1/4885SUV39H2 3078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.