Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28949638 | 0.86 | — | — | |
| SCHEMBL27837994 | 0.78 | MAPT (0.32) | ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL28825963 | 0.77 | KLKB1 (0.38) | — | |
| SCHEMBL27699978 | 0.76 | — | — | |
| SCHEMBL28868753 | 0.74 | LDHA (0.41) | LDHAALDH1A1POLBSMN1; SMN2TSHR | |
| SCHEMBL28825902 | 0.73 | LDHA (0.40) | LDHAALDH1A1POLBSMN1; SMN2TSHR | |
| SCHEMBL27809350 | 0.73 | — | — | |
| SCHEMBL21995563 | 0.72 | CYP1A2 (0.51) | LDHAFABP4ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL21995565 | 0.72 | CYP1A2 (0.51) | LDHAFABP4ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL27742901 | 0.71 | SLC6A2 (0.32) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102216285-B | Tetrasubstituted pyridazine hedgehog pathway antagonists | LILLY CO ELI | 2014-08-13 | — | — | CN | disclosed |
| CN-102216285-A | Tetrasubstituted pyridazine hedgehog pathway antagonists | LILLY CO ELI | 2011-10-12 | — | — | CN | disclosed |