Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680305 | 0.91 | PLK4 (0.39) | PLK4NTRK1RETMETAXL | |
| SCHEMBL680355 | 0.84 | PLK4 (0.53) | PLK4NTRK1RETMETAXL | |
| SCHEMBL679314 | 0.79 | RXRA (0.38) | SCN9AHSPB1ALDH1A1MAPTMAPK1 | |
| SCHEMBL679898 | 0.79 | RXRA (0.38) | PLK4NTRK1RETMETAXL | |
| SCHEMBL680423 | 0.79 | EGFR (0.39) | KDRSCN9AHSPB1MAPTMAPK1 | |
| SCHEMBL680923 | 0.78 | CYP11B1 (0.40) | METSCN9AHSPB1ALDH1A1MAPT | |
| SCHEMBL680965 | 0.77 | RXRA (0.40) | PLK4NTRK1RETMETAXL | |
| SCHEMBL680130 | 0.77 | ATR (0.38) | SCN9A | |
| SCHEMBL680020 | 0.76 | EGFR (0.39) | KDRSCN9AHSPB1 | |
| SCHEMBL680764 | 0.76 | RXRA (0.40) | SCN9AHSPB1ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102105462-A | Amidophenoxyindazoles useful as inhibitors of C-MET | LILLY CO ELI | 2011-06-22 | — | — | CN | disclosed |