Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27821973 | 0.87 | NOS2 (0.43) | NOS2TLR7ADORA2AADORA2BCNR2 | |
| SCHEMBL27836956 | 0.82 | NOS2 (0.40) | NOS2TLR7ADORA2AADORA2BCNR2 | |
| SCHEMBL7272832 | 0.81 | NOS2 (0.44) | NOS2TLR7ADORA2AADORA2BCNR2 | |
| SCHEMBL1292982 | 0.81 | ADORA2A (0.40) | ADORA2AADORA2B | |
| SCHEMBL11070333 | 0.81 | CNR2 (0.43) | NOS2TLR7CNR2CNR1KCNH2 | |
| SCHEMBL28945481 | 0.80 | NOS2 (0.38) | NOS2TLR7CNR2KCNH2HRH4 | |
| SCHEMBL11691084 | 0.79 | ADORA2A (0.45) | NOS2ADORA2AADORA2BHRH3 | |
| SCHEMBL27841280 | 0.79 | TLR7 (0.37) | NOS2TLR7ADORA2AADORA2BCNR2 | |
| SCHEMBL27821985 | 0.77 | TLR7 (0.36) | NOS2TLR7ADORA2AADORA2BCNR2 | |
| SCHEMBL27841283 | 0.77 | RAB9A (0.39) | NOS2TLR7CNR2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105308046-A | Kinase inhibitors | CHIESI FARMA SPA | 2016-02-03 | — | — | CN | disclosed |
| CN-102026985-A | Quinazoline derivatives as RAF kinase modulators and methods and uses thereof | AMBIT BIOSCIENCES CORPORATON | 2011-04-20 | — | — | CN | disclosed |