Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879218 | 0.81 | CHRNB2 (0.36) | TSHRMAPK1SMN1; SMN2L3MBTL1CHRNB2 | |
| SCHEMBL28604807 | 0.81 | CHRNB2 (0.36) | TSHRMAPK1SMN1; SMN2L3MBTL1CHRNB2 | |
| SCHEMBL11232065 | 0.79 | ICMT (0.35) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL10976001 | 0.76 | GRIN1 (0.37) | TSHRMAPK1SMN1; SMN2L3MBTL1CHRNB2 | |
| SCHEMBL11247257 | 0.76 | GRIN1 (0.35) | TSHRMAPK1SMN1; SMN2L3MBTL1CHRNB2 | |
| SCHEMBL11231723 | 0.75 | GRIN1 (0.37) | TSHRMAPK1SMN1; SMN2L3MBTL1CHRNB2 | |
| SCHEMBL873359 | 0.74 | CHRNB2 (0.41) | TSHRL3MBTL1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL10975428 | 0.73 | TSHR (0.34) | TSHRCHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL10852241 | 0.73 | SLC6A2 (0.41) | MAPK1CHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL919634 | 0.72 | ALDH1A1 (0.38) | TSHRCHRNB2SLC6A2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699759-B1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-20 | — | — | EP | disclosed |